Many applicants these days are applying to every open position they find. This is not only a waste of time and resources but also a source of frustration when efforts result in minimum responses from employers. Instead, applicants need to focus on the companies that are looking for your skill sets, education, experience, etc. For the applicants who wish to change career paths, they will need to write about their transferrable skills into the new career path and explain how and why they will fit into the company. In both cases, what will set you apart from other applicants is knowledge about the company and knowledge about yourself. The better you know both, the better you can persuade a hiring manager to bring you aboard.